In the analysis of gene expression in whole proteasomes including PSMB5 (β5), PSMB8 (iβ5), PSMB7 (β2), PSMB10 (iβ2), PSMB6 (β1), and PSMB9 (iβ1), these genes alternated or showed only slight in their expression following silencing of PSMB5 or PSMB7 in three tumor cells (Figure 6D). This evidence concerns the gene PSMB8 and neoplasm.