In the analysis of gene expression in whole proteasomes including PSMB5 (β5), PSMB8 (iβ5), PSMB7 (β2), PSMB10 (iβ2), PSMB6 (β1), and PSMB9 (iβ1), these genes alternated or showed only slight in their expression following silencing of PSMB5 or PSMB7 in three tumor cells (Figure 6D). The gene discussed is PSMB10; the disease is neoplasm.