PANTHER pathways analysis of differentially expressed proteins revealed overrepresentation of Wnt signaling pathway (CDH1, CSNK2A2, GNA11, CTBP2, CDH17, SMARCE1, p-value 0.02), followed by Alzheimer disease-presenilin pathway (MMP8, MMP9, MLLT4, CDH1, P-value 0.04). The gene discussed is MMP8; the disease is early-onset autosomal dominant Alzheimer disease.