JAK2 and Hodgkins lymphoma: Inhibition of JAK2 by fedratinib in HL and mediastinal large B-cell lymphoma (MLBL) has been significantly associated with an inhibition of cell proliferation and decreased growth in MLBL xenografted non-obese diabetic severe combined immunodeficiency gamma (NSG) mice, further establishing the importance of JAK2 activation in these tumors [26].