Our data favors a tumor suppressor function for C/EBPβ in renal tumor and similar to breast cancer altered expression of transcriptionally inactive C/EBPβ (LIP) or suppression of expression of transcriptionally active C/EBPβ (LAP) could in part contribute to renal tumor progression by modulating target genes such as TMIGD1. This evidence concerns the gene TMIGD1 and kidney neoplasm.