Interestingly, forced hypomethylation and de-repression of TDRD9 by 5-aza-2 ́-deoxycytidine treatment of TDRD9-negative cells, does not promote a stable de-repression of the gene, suggesting that TDRD9 expression does not confer a general selective advantage for all lung carcinoma tumor cells. This evidence concerns the gene TDRD9 and neoplasm.