Another study by Montironi et al in 2007 showed that endothelin-1 expression was not limited to the late prostate cancer phases and was also seen in HGPIN found in radical prostatecromy and also clinically insignificant prostate cancers in cystoprostatectomy specimen; however the number of their cases was limited in each groups (22). The gene discussed is EDN1; the disease is prostate carcinoma.