For instance, Chuan shu et al., reported that arsenic played a fundamental role to activate signaling mediators including miR-199/148 / ERBB2 / PKM2 / NF-kB to increase the expression of hypoxia-inducible factor 1 (HIF-1), interleukin (IL)-8, and finally increased angiogenesis and contributed to the processes of tumor progression and development (36). Here, PKM is linked to neoplasm.