Histones around TNFA are highly acetylated in monoyctes (73)histone H4 of monocytes is hyperacetylated (74–76)H3K4me3 of SLE monocytes are associated with inflammation and immune response-related genes (78, 79)SLE-specific H3K4me3 and H3K27me3 (enhancer) modifications (55, 77). Here, TNF is linked to systemic lupus erythematosus.