Also, the administration of anti-fibrotic agents, in several murine tumor models (E-G7 lymphoma, LLC1 Lewis lung cancer, or B16F1 melanoma) induced a strong increment of CD8+ T cells, NK activity, and humoral immunity and a sharp decrease of MDSC, Treg, stromal-derived factor 1, TGF-β, and PGE2 (162). The gene discussed is TGFB1; the disease is neoplasm.