ERVW-1 and infection: Regarding the trans-infection cell-to-cell process from DCs, several studies showed that DCs can capture HIV-1 through binding of the viral envelope glycoproteins to the mannose specific C-type lectin receptor (DC-SIGN) and store viruses into tetraspanin-enriched compartments, in continuity with the plasma membrane without viral replication in recipient DCs (58, 83, 84, 87).