Provasi et al., using zinc finger nucleases against the endogenous TCR α and β genes, managed to edit Tg T-cells to express only Willms tumor-1 (WT-1)-specific TCRs in a Hu-PBL-severe combined immunodeficiency (SCID) animal model, a SCID mouse grafted with human peripheral blood lymphocytes, of WT-1+ leukemia. The gene discussed is WT1; the disease is combined immunodeficiency.