ERBB2 and congenital rubella syndrome: An example that would confirm this hypotheses would be the fact that one in vivo study involves CAR T-cells targeting the Her2/neu antigen, proving the antineoplastic activity and the biological safety of Her2/neu-specific CAR T-cells in transgenic animals with lymphodepletion (157), yet the clinical trial involving the same engineered cells showed that one of the patients died due to a massive CRS (158).