TNFAIP3 and systemic lupus erythematosus: For instance, specific SNPs associated with SLE (“TT>A”, Figure 2H) are situated in an enhancer region of the TNFAIP3 gene and hamper DNA looping, resulting in reduced TNFAIP3 mRNA expression (122) and reduced A20/TNFAIP3 protein expression in B-cells (8).