NLRP3 and myocardial infarction: Indeed, in the setting of acute experimental myocardial infarction, NLRP3 deletion or pharmacological inhibition reduced infarct size (Mezzaroma et al., 2011; Marchetti et al., 2014), whilst activation of NLRP3 led to inflammasome hyperactivation and amplified cardiac injury (Mezzaroma et al., 2011).