Studies suggest that NLRP1 and NLRP3 activity levels alter metabolic homeostasis and can thereby contribute to glucose intolerance and insulin resistance (Stienstra et al., 2010, 2011; Vandanmagsar et al., 2011; Wen et al., 2011; Youm et al., 2011; Murphy et al., 2016). Here, NLRP1 is linked to Insulin resistance.