NLRP3 and diabetic cardiomyopathy: Furthermore, Rosuvastatin, a 3-hydroxy-3- methylglutaryl coenzyme A reductase inhibitor shown to have anti-inflammatory and anti-oxidant properties in several disease pathologies (Sharma et al., 2011; Zhang et al., 2012), conferred improvements in the setting of diabetic cardiomyopathy, via an NLRP3 inflammasome-dependent mechanism (Luo et al., 2014b).