In the liver of a hypertensive rat HFC diet-induced NASH model, a low molecule chymase inhibitor attenuated the levels of chymase as well as MMP-9, TGF-β and collagen I, which are all chymase-associated factors (Miyaoka et al., 2017). The gene discussed is TGFB1; the disease is metabolic dysfunction-associated steatohepatitis.