FOXC1 and coloboma: However, conclusions on the role of neural crest POM in early eye development are not clearcut; indeed loss of function of some genes impacting neural crest derived-POM, such as Foxc1 in mouse, does not appear to lead to coloboma and Foxc1 mutations in humans are only rarely associated with coloboma (Kidson et al., 1999; Kaur et al., 2009; Tümer and Bach-Holm, 2009).