Examples of proteins associated with LCA are for instance RPE65 (retinoid isomerase), guanylate cyclase (abbreviated GC-E, RetGC1 or ROS-GC1) and RD3 (retinal degeneration 3 protein) (Perrault et al., 2000; den Hollander et al., 2008; Cideciyan, 2010; Preising et al., 2012). This evidence concerns the gene GUCY2D and Leber congenital amaurosis.