In superoxide dismutase 1 (SOD1) G93A transgenic mouse, a model for ALS, depletion of Rtn4 accelerates disease onset and progression possibly by disrupting normal distribution of protein disulfide isomerase (PDI), suggesting protective role of Reticulon in motor neuron degeneration (Yang et al., 2009). This evidence concerns the gene P4HB and amyotrophic lateral sclerosis.