Additionally, several SG components, including eIF3 and TIA-1, have been found in aggregates in post-mortem ALS tissue (Liu-Yesucevitz et al., 2010), and a recent report has identified TIA-1 as a rare causative mutation for fALS (Mackenzie et al., 2017). This evidence concerns the gene EIF3A and amyotrophic lateral sclerosis.