This is in contrast to previous reports that have shown increased numbers of SGs in in vitro models of SOD1-, TDP-43-, or C9orf72-linked ALS (Liu-Yesucevitz et al., 2010; Dafinca et al., 2016; Mateju et al., 2017). The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.