Liao et al. [49] reported soluble VCAM-1 to be an early biomarker of severe dengue versus dengue fever in adults infected with DENV-1, and Mangione et al. [50] similarly associated soluble VCAM-1 with pediatric dengue shock syndrome, in comparison to dengue fever and dengue hemorrhagic fever. The gene discussed is VCAM1; the disease is dengue disease.