Infection with PUO-312 resulted in similar changes in transcript expression to those observed with the laboratory clone: increased TNF-α in retinal pigment epithelial cells and retinal endothelial cells (not statistically significant for endothelial cells); increased IFN-β in retinal pigment epithelial cells and retinal endothelial cells; increased VCAM-1 in retinal endothelial cells; and decreased CTNNB1 in retinal pigment epithelial cells, but not retinal endothelial cells (Figure S1 C and D, resp). This evidence concerns the gene CTNNB1 and infection.