In order to evaluate a potential role of AKR1C1-4 on the phenomenon of therapy resistance in T-ALL, we analysed the expression levels, at diagnosis, of a series of NRF2-AKR1C axis components including NRF2, KEAP1, CUL3, and AKR1C1-4 in 48 patients for which the transcriptional profile was generated (Suppl. Here, CUL3 is linked to acute lymphoblastic leukemia.