HDAC8 and neuroblastoma: ALK expression studies using two publicly available neuroblastoma cohorts in the R2 database [26], the Academic Medical Center (AMC) cohort with 88 patient samples and the large cohort of neuroblastoma cases (n = 649) from the German Neuroblastoma Trial [27], revealed a strong correlation with HDAC8 expression (Fig. 3a, b).