SLC6A3 and Brain atrophy: A diffuse, nonspecific brain atrophy was observed only in the Sicilian family by MRI, whereas a marked decrease of dopamine transporter density in the striatum has been found in all the patients subjected to single-photon emission computed tomography with intravenous injection of 185 MBq of [123I]FP-CIT (DaT-SCAN)17,19.