EGF and non-small cell lung carcinoma: Recently, it was reported that KGA activity was stimulated by EGF and regulated by Raf-1/Mek/Erk signaling in 293T cells.14 In NSCLC cells, GAC has been determined to be the predominant GLS1 isoform.33 Therefore, it is of important clinical relevance to elucidate the mechanism regulating GAC activity in NSCLC cells.