The splicing signature comparison analysis (Figure 5, see Methods) using splicing signatures from the human psoriasis dataset and the four datasets of the three human SF perturbation showed significantly overlapped splicing changes between the human psoriasis dataset and the SF perturbation datasets of three human SFs— i.e., PTBP1, U2AF1, and MBNL1 (Table S4). The gene discussed is U2AF1; the disease is psoriasis.