TNIP1 and psoriasis: It has been shown that Tnip1 knockout (KO) mice exhibit macroscopical psoriasis-like phenotypes, such as redness and scaling, and microscopical psoriasis-like phenotypes, such as epidermal thickening, elongated rete-like ridges, papillomatosis, retention of nuclei within corneocytes, and infiltrations with different immune cell types16.