The frequency of CD4+, DN and CD8+ subsets of MAIT cells, defined through antibody gating, showed a moderate but significant reduction in the proportion of CD8+ MAIT cells and a reciprocal increase in DN and CD4+ MAIT cells between healthy and untreated MM patients, that was not apparent in the R/R cohort (Fig. 1C). The gene discussed is CD8A; the disease is Miyoshi myopathy.