Next, we examined the impact of BKM120 on the proliferation of B-NHL, including cell lines from mantle cell lymphoma (MINO, JEKO-1, REC-1, MAVER-1, and GRANTA-519), Burkitt lymphoma (CA-46, DG-75) and diffuse large B-cell lymphoma (SU-DHL-10). This evidence concerns the gene RAD1 and Burkitt lymphoma.