Furthermore, as DNA ploidy appears to have a negative impact on prognosis in general and on the tendency to metastasize in particular54,55, BKM120-mediated formation of polyploid cells may have therapeutic relevance as loss  of  Bax and Bak is observed in high-grade NHL and also contributes to NHL resistance against rituximab and chemotherapy56,57. Here, BAX is linked to non-Hodgkin lymphoma.