Consistently, compared to mice engrafted with empty lentiviruses, mice engrafted with wild-type SuFu showed a reduced tumour growth rate, a reduced tumour volume (at the end point of experiment) (Fig. 6c–e), a decreased labelling of Ki67 and Gli1 (the final downstream target of Hh signalling) (Fig. 6f, g), and an increased expression of the Gli3 repressor form (Fig. 6h). The gene discussed is GLI3; the disease is neoplasm.