CRLF1 and thyroid gland undifferentiated (anaplastic) carcinoma: Compared with those in a normal epithelial cell line (Nthy-ori-3-1), CRLF1 mRNA and protein levels were increased in a PTC cell line (B-CPAP) and an anaplastic thyroid carcinoma (ATC) cell line (8305C) (Figs. 2b, d).