For example, it has been reported that NEAT1 can promote lung cancer progression through the miR-377-3p–E2F3 axis, regulate EMT through the miR-204/ZEB1 pathway in nasopharyngeal carcinoma, and serves as a downstream target of ERα to play a critical role in carcinogenesis of prostate cancer12,20,28. The gene discussed is ESR1; the disease is lung cancer.