Our results indicate that HCC cells exhibited adistinctive profile of stemness-related genes according to their TGF-β-dependentsignature: early (epithelial, responding to the suppressor effects of TGF-β) or late(mesenchymal with autocrine production of TGF-β and unresponsive to its suppressoreffects). Here, TGFB1 is linked to hepatocellular carcinoma.