After LPS interacts with specific receptors such as Toll-like receptor 4 (TLR-4) (Solov'eva et al., 2013) on host immune cells, inflammatory cytokines like IL-1, TNF-α, and IL-6 are secreted, leading to hemodynamic alteration, widespread inflammation, and sepsis (Solov'eva et al., 2013). The gene discussed is TLR4; the disease is Sepsis.