The phenotype of epidermis-located MataHari T cells showed increasing divergence over time from their counterparts located in SLOs, with the former differentiating into CD103+CD69+ resident memory T cell–like (TRM-like) cells several weeks following the induction of GVHD (at day 21, 24.9% ± 8.7% in epidermis versus 2.4% ± 1.4% in LNs, n = 7/group pooled from 2 experiments, P = 0.02, 2-tailed Wilcoxon’s rank-sum test). This evidence concerns the gene CD69 and graft versus host disease.