CD8A and graft versus host disease: To exclude the former possibility that the observed differences in TE gene expression between the SLOs and GVHD target organs related to preexisting variation in TCR repertoire (for example, due to selective expansion of atypical TE clones recognizing antigens expressed uniquely in one set of tissues), we repeated these experiments in an additional B6 female → B6 male (F→M) BMT model involving transfer of naive MataHari CD8+ T cells transgenic for a TCR that recognizes a single, ubiquitous HY antigen, Db‐Uty (20, 21) (Figure 2A).