M29 segregated with the majority of GVHD target organs and can be considered a pan-GVHD target organ gene cluster; drivers included genes encoding receptors (e.g., Tnfr2), adaptors (e.g., Traf1/4, Gadd45b, and Nr4a2), and TFs that regulate Th/Tc1 and Th/Tc17 proinflammatory cytokine generation (e.g., Rel, Fosl2, Kdm6b, Skil, and Chd7). Here, TRAF1 is linked to graft versus host disease.