To test whether TE gene modules correlating with target tissues that we identified in experimental GVHD would also be conserved at similar locations in human patients developing GVHD, we performed RNA sequencing (RNAseq) on CD8+ T cells obtained simultaneously from the blood and epidermis of 5 patients at the onset of acute pattern skin GVHD (Supplemental Table 2). The gene discussed is CD8A; the disease is graft versus host disease.