L-arginine supplementation in malaria-infected dams also resulted in changes to angiogenic mediators, with an up-regulation of Tie-2 (P < 0.01; Fig. 6D) and Ang-1 (P < 0.05; Fig. 6E) and a down-regulation of Ang-2 (P < 0.05; Fig. 6F). The gene discussed is TEK; the disease is malaria.