Because kenpaullone was a candidate therapeutic for amyotrophic lateral sclerosis and cardiac parasympathetic dysfunction (Yang et al., 2013; Zhang et al., 2014), our findings suggest that CDK2 might also contribute to the protective effects of kenpaullone against amyotrophic lateral sclerosis and cardiac parasympathetic dysfunction. The gene discussed is CDK2; the disease is amyotrophic lateral sclerosis.