The top five significant pathways included adherens junction (path:hsa04520, P = 5.34 × 10−3), insulin secretion (path:hsa04911, P = 7.32 × 10−3), other types of O-glycan biosynthesis (path:hsa00514, P = 0.0101), pathways in cancer (path:hsa05200, P = 0.0148), and pancreatic cancer (path:hsa05212, P = 0.0156). This evidence concerns the gene INS and familial pancreatic carcinoma.