In order to rule out the possibility that the observed differences in the levels of phosphorylated proteins and phosphorylation response were caused by differences in the absolute levels of those proteins, we measured the total levels of p38MAPK, Erk1/2, STAT1, and STAT6 (the ones that showed the most significant differences between patients and controls) in a subgroup of RRMS patients and controls. This evidence concerns the gene MAPK3 and relapsing-remitting multiple sclerosis.