RUNX3 and acute myeloid leukemia: We next determined whether this differential interaction between VS-5584 and ICG-001 is unique to this TF1 pair cells, we treated 2 additional AML cell lines with one PRL-3 high (MOLM-14) and one PRL-3 low (OCI-AML2), with VS-5584 and ICG-001, alone and in combination, monitored cell proliferation by CTG assay, and similarly analyzed the data for synergy.