Pathway enrichment analysis for female Smoker vs COPD groups revealed 6 significantly enriched pathways (q < 0.05, Table 2, Additional file 2: Table S3): oxidative phosphorylation, citrate cycle, glutathione metabolism, FcγR-mediated phagocytosis, lysosomal pathway and regulation of actin cytoskeleton. This evidence concerns the gene FCGR2A and chronic obstructive pulmonary disease.