In the current study, expression of Itgam, Nov, and Stab 2 increased and Ppard decreased in Il18−/− mice (Table 3), suggesting that increased levels of Itgam and Nov and decreased expression of Ppard led to kidney damage in youth-aged mice, although high levels of Stab 2 might show some protective effects. The gene discussed is PPARD; the disease is Nephropathy.