Notably, 31 out of the top 50 genes identified by informME, such as SALL3, HOXA5, SOX1, ZIC1, CBLN1, AJAP1, DIO3, GFRA1, and FOXC2, have been already associated with lung cancer (Additional file 2: Table S4). The gene discussed is DIO3; the disease is lung carcinoma.