We identified many genes with this property that have been implicated in lung cancer, such as AJAP1, CBLN1, FOXC2, OLIG2, POU3F3, SALL3, and SOX1. For example, the genomic regions depicted in Fig. 9 contain AJAP1 and CBLN1, which are respectively ranked 16-th and 14-th in the JSD-based lists of ranked genes obtained by informME in the case of the lungcancer-2-VS-lungnormal-2 and lungcancer-1-VS-lungnormal-1 comparisons (Additional file 2: Table S8). The gene discussed is SALL3; the disease is lung cancer.