Although both deaths from cryptococcosis and unknown causes were predicted by low CD4 count, other predictors differed, in particular symptoms (fever) and metabolic derangements, consistent with deaths from unknown causes not being primarily due to undiagnosed cryptococcosis, and at least some being due to SBIs and/or other undiagnosed infections such as tuberculosis and atypical mycobacteria. Here, CD4 is linked to infection.