Taking this into consideration, WHO strongly recommends that a package of care be offered to those presenting with advanced HIV disease; depending on age and CD4 cell count, the package may include opportunistic infection screening and prophylaxis, including fluconazole preemptive therapy for those who are CrAg positive and without evidence of meningitis, TB symptom screen, diagnostic workup, treatment when appropriate, and TB preventive therapy in those without TB symptoms. The gene discussed is CD4; the disease is Opportunistic infection.