The objective of our study was to evaluate the effects of alcohol, diabetes and their association on miRNA-155 and miRNA-199 and endothelin receptors (ETA and ETB) in the corpus cavernosum and blood of rats submitted to the experimental model of diabetes mellitus and "semi-voluntary chronic alcoholism", and investigate whether there is a relationship between miRNAs and endothelin receptors. This evidence concerns the gene EDNRB and diabetes mellitus.