TNF and type 2 diabetes mellitus: In the context of T2D, for example, a study has shown that MFs cultured under physiologically relevant hyperglycaemic conditions display hypo responsiveness to IL-10, resulting in a failure to down-regulate TNF-α production, implying that a reduction of IL-10 activity in MFs may contribute to the chronic low-grade inflammation seen in T2D (Barry et al. 2016).