One protein that has been implicated to cause insulin resistance is ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) or plasma cell membrane glycoprotein 1, which is thought to hydrolyze ATP to generate inorganic pyrophosphate (PPi) plus AMP or inorganic phosphate (Pi) plus ADP (6). This evidence concerns the gene ENPP1 and Insulin resistance.