TNF and ulcerative colitis: Surprisingly, the model shows that a knockout of IL2 leads to a reduction in MMPs similar to that of a knockout of TNFα, even when previous results of clinical trials with Basiliximab or Daclizumab (monoclonal antibodies that bind to the interleukin 2 receptor CD25) in Ulcerative Colitis have failed to show superiority to corticosteroids alone [73,74].