In univariate analysis, the following factors with neurological manifestations in chronic hepatitis C patients; age ≥55 years (p = 0.002), being overweight (p = 0.007), longer duration of infection (p = 0.016), fasting blood glucose ≥1g/l (p = 0.04), total cholesterol ≥2g/l (p = 0.04) and serum albumin < 35g/l (p = 0.02) and, high viral load was associated with neurological manifestations (p = 0.05). The gene discussed is ALB; the disease is infection.