Our observation of failure of these meiotic functions of BRDT provides insight into the infertility in the Brdt mouse models [6, 8] and in individuals reported as carrying polymorphisms in the BRDT gene [9, 10], as well as the possibility that BET protein inhibitors might be considered as a non-hormonal approach to male contraception [11]. The gene discussed is DNER; the disease is Infertility.