For instance, we find that hsa-mir-497 and hsa-mir-7-2 have an epistatic interaction and they share two common target genes, namely APC and KRAS. These two target genes belong to the Wnt signaling pathway and EGFR signaling pathway separately, which are involved in the development of colon cancer [42, 43]. This evidence concerns the gene KRAS and malignant colon neoplasm.