It was reported that HO‐1 overexpression protects doxorubicin‐induced dilated cardiomyopathy via inhibiting Fis1 and increasing Mfn1/Mfn2 expression, suggesting that HO‐1 plays a critical role in mediating mitochondrial dynamics to regulate heart function.20 This evidence concerns the gene HMOX1 and dilated cardiomyopathy.